IL-17-producing γδ T cells enhance bone regeneration

• DOI: 10.1038/ncomms10928
• Publication Date: 2016-03-11T11:31:59Z
• Authors: Takehito Ono; Kazuo Okamoto; Tomoki Nakashima; Takeshi Nitta; Shohei Hori; Yoichiro Iwakura; Hiroshi Takayanagi
• Keywords: Bone tissue; Bone cell

Abstract Immune responses are crucial not only for host defence against pathogens but also tissue maintenance and repair after injury. Lymphocytes involved in the healing process injury, including bone fracture muscle damage. However, specific immune cell subsets mediators of entirely clear. Here we show that γδ T cells produce IL-17A, which promotes formation facilitates healing. Repair is impaired IL-17A-deficient mice due to a defect osteoblastic formation. IL-17A accelerates by stimulating proliferation differentiation mesenchymal progenitor cells. This study identifies novel role IL-17-producing skeletal regeneration.