RETRACTED ARTICLE: SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin

• DOI: 10.1038/ncomms11996
• Publication Date: 2016-06-29T10:52:31Z
• Authors: Lei Dai; Xueliang Cui; Xin Zhang; Lin Cheng; Yi Liu; Yang Yang; Ping Fan; Qingnan Wang; Yi Lin; Junfeng Zhang; Chunlei Li; Ying Mao; Qin Wang; Xiaolan Su; Shuang Zhang; Yong Peng; Hanshuo Yang; Xun Hu; Jinliang Yang; Meijuan Huang; Rong Xiang; Dechao Yu; Zongguang Zhou; Yuquan Wei; Hongxin Deng
• Keywords: Ceruloplasmin

SARI, also called as BATF2, belongs to the BATF family and has been implicated in cancer cell growth inhibition. However, role mechanism of SARI tumour angiogenesis are elusive. Here we demonstrate that deficiency facilitates AOM/DSS-induced colonic tumorigenesis mice. We show is a novel inhibitor colon Antibody array HUVEC-related assays indicate VEGF an essential SARI-controlled inhibition angiogenesis. Furthermore, Co-IP/PAGE/mass spectrometry indicates directly targets ceruloplasmin (Cp), induces protease degradation Cp, thereby inhibiting activity HIF-1α/VEGF axis. Tissue microarray results expression inversely correlates with poor clinical outcomes patients. Collectively, our potential target for therapy by through reduction prognostic indicator patients cancer.