Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig

• DOI: 10.1038/ncomms13052
• Publication Date: 2016-10-07T09:08:57Z
• Authors: Jianzhao Liu; Yuanxiang Zhu; Guan-Zheng Luo; Xinxia Wang; Yanan Yue; Xiaona Wang; Xin Zong; Kai Chen; Hang Yin; Ye Fu; Dali Han; Yizhen Wang; Dahua Chen; Chuan He
• Keywords: Epigenomics; Deoxyadenosine

Abstract DNA N 6 -methyldeoxyadenosine (6mA) is a well-known prokaryotic modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report 6mA accumulates up ∼0.1–0.2% of total deoxyadenosine during early embryogenesis vertebrates, but diminishes the background level with progression embryo development. During this process large fraction 6mAs locate repetitive regions genome.