CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells

• DOI: 10.1038/ncomms13373
• Publication Date: 2016-11-14T10:32:05Z
• Authors: Jae-Ho Cho; Hee-Ok Kim; Young-Jun Ju; Yoon-Chul Kye; Gil-Woo Lee; Sung-Woo Lee; Cheol-Heui Yun; Nunzio Bottini; Kylie Webster; Christopher C. Go...; Charles D. Surh; Cecile King; Jonathan Sprent
• Keywords: 570; 1.1 Normal biological development and functioning; Cells; Knockout; Science; Immunology; Receptors, Antigen, T-Cell; 610; 32 Biomedical and Clinical Sciences; Mice, Transgenic; CD8-Positive T-Lymphocytes; Inbred C57BL; CD5 Antigens; Lymphocyte Activation; Transgenic; Article; Vaccine Related; Mice; 03 medical and health sciences; anzsrc-for: 32 Biomedical and Clinical Sciences; 0302 clinical medicine; Receptors; 2.1 Biological and endogenous factors; Animals; RESUBMITTED LOTS; Aetiology; Cells, Cultured; anzsrc-for: 3204 Immunology; Mice, Knockout; Cultured; Biomedical and Clinical Sciences; Inflammatory and immune system; Q; ACCEPTANCE; T-Cell; INSPECTION; 3204 Immunology; Mice, Inbred C57BL; Antigen; Interleukin-2; Leukocyte Common Antigens; Immunization; Immunotherapy; Immunologic Memory

Abstract Continuous contact with self-major histocompatibility complex (MHC) ligands is essential for survival of naïve T cells but not memory cells. This surprising finding implies that cell subsets may vary in their relative T-cell receptor (TCR) sensitivity. Here we show CD8 + TCR sensitivity correlates inversely levels CD5, a marker strong self-MHC reactivity. We also lower than In both situations, hypo-responsiveness applies only to short-term signalling events and proliferation, directly increased expression phosphatase, CD45 reciprocal decreased activated LCK. Inhibition by high on protect against overt auto-MHC reactivity, while enhanced cytokines ensures responses foreign antigens.