Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20

• DOI: 10.1038/ncomms14824
• Publication Date: 2017-03-22T10:50:37Z
• Authors: Gan Liu; Luting Zhou; Hai Zhang; Rong Chen; Ye Zhang; Ling Li; Jun-Yu Lu; Hui Jiang; Dong Liu; Shasha Qi; Ying-Ming Jiang; Kai Yin; Zhifang Xie; Yuguang Shi; Yong Liu; Xuetao Cao; Yu-Xia Chen; Dajin Zou; Weiping J. Zhang
• Keywords: Lipogenesis; Carbohydrate-responsive element-binding protein; Steatosis; Knockout mouse

Abstract Hepatic de novo lipogenesis (DNL) converts carbohydrates into triglycerides and is known to influence systemic lipid homoeostasis. Here, we demonstrate that the zinc finger protein Zbtb20 required for DNL. Mice lacking in liver exhibit hypolipidemia reduced levels of triglycerides, along with impaired hepatic lipogenesis. The expression genes involved glycolysis DNL, including two ChREBP isoforms, decreased livers knockout mice. binds enhances activity ChREBP-α promoter, suggesting altered metabolic gene mainly driven by ChREBP. In addition, ChREBP-β overexpression largely restores glucose metabolism, increases plasma triglyceride Finally, show ablation protects from diet-induced steatosis improves insulin resistance. We suggest ZBTB20 an essential regulator may be a therapeutic target treatment fatty disease.