Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections

• DOI: 10.1038/ncomms1677
• Publication Date: 2012-02-14T09:44:21Z
• Authors: Takayuki Matsumura; Manabu Ato; Tadayoshi Ikebe; Makoto Ohnishi; Haruo Watanabe; Kazuo Kobayashi
• Keywords: Adoptive Cell Transfer; Monocyte

Cytokine-activated neutrophils are known to be essential for protection against group A Streptococcus infections. However, during severe invasive infections that accompanied by neutropenia, it remains unclear which factors protective such infections, and cell population is the source of them. Here we show mice infected with isolates, but not non-invasive exhibit high concentrations plasma interferon-γ early stage infection. Interferon-γ necessary protect mice, produced a novel granulocyte–macrophage colony-stimulating factor-dependent immature myeloid cells ring-shaped nuclei. These interferon-γ-producing express monocyte granulocyte markers, also produce nitric oxide. The adoptive transfer ameliorates infection in wild-type interferon-γ-deficient mice. Our results indicate have role Myeloid important response invasiveStreptococcusGroup A. In this study, distinct ring shaped nuclei shown stages