Bio-inspired detoxification using 3D-printed hydrogel nanocomposites

• DOI: 10.1038/ncomms4774
• Publication Date: 2014-05-08T10:19:30Z
• Authors: Maling Gou; Xin Qu; Wei Zhu; Mingli Xiang; Jun Yang; Kang Zhang; Yuquan Wei; Shaochen Chen
• Keywords: Detoxification; Matrix (chemical analysis); 3d printed

Rationally designed nanoparticles that can bind toxins show great promise for detoxification. However, the conventional intravenous administration of detoxification often leads to nanoparticle accumulation in liver, posing a risk secondary poisoning especially liver-failure patients. Here we present liver-inspired three-dimensional (3D) device. This device is created by 3D printing designer hydrogels with functional polydiacetylene installed hydrogel matrix. The attract, capture and sense toxins, while matrix modified liver lobule microstructure allows be trapped efficiently. Our results toxin solution completely loses its virulence after treatment using this biomimetic work provides proof-of-concept 3D-printed nanocomposite construct hydrogel, could lead development alternative platforms.