NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2

• DOI: 10.1038/ncomms6176
• Publication Date: 2014-11-07T10:15:18Z
• Authors: Haejin Yoon; Hye-Lim Kim; Yang-Sook Chun; Dong Hoon Shin; Kyoung-Hwa Lee; Chan Soo Shin; Dong Yeon Lee; Hong-Hee Kim; Zang Hee Lee; Hyun-Mo Ryoo; Mi-Ni Lee; Goo Taeg Oh; Jong-Wan Park
• Keywords: RUNX2; Negative regulator; Bone Formation

Runt-related transcription factor 2 (Runx2) transactivates many genes required for osteoblast differentiation. The role of N-α-acetyltransferase 10 (NAA10, arrest-defective-1), originally identified in yeast, remains poorly understood mammals. Here we report a new NAA10 function Runx2-mediated osteogenesis. Runx2 stabilizes osteoblasts during BMP-2-induced differentiation, and turn controls this differentiation by inhibiting Runx2. delays bone healing rat calvarial defect model development neonatal mice. Mechanistically, acetylates at Lys225, acetylation inhibits Runx2-driven interfering with CBFβ binding to Our study suggests that acts as guard ensuring balanced osteogenesis fine-tuning signalling feedback manner. inhibition could be considered potential strategy facilitating formation. N-alpha-acetyltransferase (NAA10) regulates cell growth proliferation. the authors show also has osteogenesis, activity osteogenic