Mudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes

• DOI: 10.1038/ncomms6594
• Publication Date: 2014-12-02T15:54:45Z
• Authors: Xinxin You; Chao Bian; Qijie Zan; Xun Xu; Xin Liu; Jieming Chen; Jintu Wang; Ying Qiu; Wujiao Li; Xinhui Zhang; Ying Sun; Shixi Chen; Wanshu Hong; Yuxiang Li; Shifeng Cheng; Guangyi Fan; Chengcheng Shi; Jie Liang; Y. Tom Tang; Chengye Yang; Zhiqiang Ruan; Jie Bai; Chao Peng; Qian Mu; Jun Lu; Mingjun Fan; Shuang Yang; Zhiyong Huang; Xuanting Jiang; Xiaodong Fang; Guojie Zhang; Yong Zhang; Gianluca Polgar; Hui Yu; Jia Li; Zhongjian Liu; Guoqiang Zhang; Vydianathan Ravi; Steven L. Coon; Jian Wang; Huanming Yang; Byrappa Venkatesh; Jun Wang; Qiong Shi
• Keywords: 0303 health sciences; Genome; Gene Expression Profiling; Sequence Analysis, DNA; Article; Immunity, Innate; Perciformes; 3. Good health; Amphibians; Evolution, Molecular; 03 medical and health sciences; Ammonia; Animals; 14. Life underwater; Hypoxia; Vision, Ocular

Mudskippers are amphibious fishes that have developed morphological and physiological adaptations to match their unique lifestyles. Here we perform whole-genome sequencing of four representative mudskippers elucidate the molecular mechanisms underlying these adaptations. We discover an expansion innate immune system genes in may provide defence against terrestrial pathogens. Several ammonia excretion pathway gills experienced positive selection, suggesting important roles mudskippers' tolerance environmental ammonia. Some vision-related differentially lost or mutated, illustrating genomic changes associated with aerial vision. Transcriptomic analyses exposed air highlight regulatory pathways up- down-regulated response hypoxia. The present study provides a valuable resource for understanding water-to-land transition vertebrates. adapted live on mudflats. Here, authors sequence genomes different mudskipper species genetic had evolutionary role