Optical focusing deep inside dynamic scattering media with near-infrared time-reversed ultrasonically encoded (TRUE) light

• DOI: 10.1038/ncomms6904
• Publication Date: 2015-01-05T12:42:11Z
• Authors: Yan Liu; Puxiang Lai; Cheng Ma; Xiao Xu; Alexander A. Grabar; Lihong V. Wang
• Keywords: Diagnostic Imaging; Light; Optical Phenomena; 610; Ear; 02 engineering and technology; 530; Dynamic Light Scattering; Mice; Animals; Computer Simulation; Ultrasonics; 0210 nano-technology

Focusing light deep inside living tissue has not been achieved despite its promise to play a central role in biomedical imaging, optical manipulation and therapy. To address this challenge, internal-guide-star-based wavefront engineering techniques—for example, time-reversed ultrasonically encoded (TRUE) focusing—were developed. The speeds of these techniques, however, were limited no greater than 1 Hz, preventing them from vivo applications. Here we improve the speed focusing scattering media by two orders magnitude, focus diffuse dynamic medium having speckle correlation time as short 5.6 ms, typical tissue. By imaging target, demonstrate first containing Since approaches decorrelation rate, work is an important step towards noninvasive optogenetics photodynamic Shaping incident allows media, but application hindered low speed. Here, Liu et al. magnitude vivolight media.