APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p

• DOI: 10.1038/ncomms7779
• Publication Date: 2015-04-10T10:56:26Z
• Authors: Kun Wang; Cui-Yun Liu; Lu-Yu Zhou; Jian-Xun Wang; Man Wang; Bing Zhao; Wen-Ke Zhao; Shi-Jun Xu; Li-Hua Fan; Xiao-Jie Zhang; Chang Feng; Chao-Qun Wang; Yan-Fang Zhao; Pei-Feng Li
• Keywords: Heart Failure; Male; 0303 health sciences; Base Sequence; Molecular Sequence Data; Primary Cell Culture; Myocardial Infarction; Oligonucleotides; Apoptosis; Autophagy-Related Protein 7; 3. Good health; Mice, Inbred C57BL; Mice; MicroRNAs; 03 medical and health sciences; Gene Expression Regulation; Autophagy; Animals; Myocytes, Cardiac; RNA, Long Noncoding; Microtubule-Associated Proteins; Signal Transduction

The abnormal autophagy is associated with a variety of cardiovascular diseases. Long noncoding RNAs (lncRNAs) are emerging as new factors in gene regulation, but how lncRNAs operate the regulation heart unclear. Here we report that long RNA, named promoting factor (APF), can regulate autophagic cell death by targeting miR-188-3p and ATG7. results show suppresses myocardial infarction Further, find APF lncRNA regulates miR-188-3p, thus affects ATG7 expression, infarction. Our present study reveals novel regulating model programme, which comprises APF, heart. Modulation their levels may serve potential targets diagnostic tools for therapeutic strategies failure. promotes cardiomyocyte molecular mechanism its unknown. Here, Wang et al.identify non-coding RNA dubbed (APF) binds inhibits turn acts on ATG7, to cardiac autophagy.