TCF12 is mutated in anaplastic oligodendroglioma

• DOI: 10.1038/ncomms8207
• Publication Date: 2015-06-12T09:48:15Z
• Authors: Karim Labreche; Iva Simeonova; Aurélie Kamoun; Vincent Gleize; Daniel Chubb; Eric Letouzé; Yasser Riazalhoss...; Sara E. Dobbins; Nabila Elarouci; Francois Ducray; Aurélien de Reyniès; Diana Zelenika; Christopher P. Wa...; Mathew Frampton; Olivier Saulnier; Tomi Pastinen; Sabrina Hallout; Dominique Figarel...; Caroline Dehais; Ahmed Idbaih; Karima Mokhtari; Jean-Yves Delattre; Emmanuelle Huillard; G. Mark Lathrop; Marc Sanson; Richard S. Houlston; ; Clovis Adam; Marie Andraud; Marie-Hélène Aubr...; Luc Bauchet; Patrick Beauchesne; Claire Blechet; Mario Campone; Antoine Carpentier; Catherine Carpentier; Ioana Carpiuc; Marie-Pierre Chenard; Danchristian Chif...; Olivier Chinot; Elisabeth Cohen-M...; Philippe Colin; Phong Dam-Hieu; Christine Desenclos; Nicolas Desse; Frederic Dhermain; Marie-Danièle Die...; Sandrine Eimer; Thierry Faillot; Mélanie Fesneau; Denys Fontaine; Stéphane Gaillard; Guillaume Gauchotte; Claude Gaultier; Francois Ghiringh...; Joel Godard; Edouard Marcel Gueye; Jean Sebastien Gu...; Selma Hamdi-Eloua...; Jerome Honnorat; Jean Louis Kemeny; Toufik Khallil; Anne Jouvet; Francois Labrousse; Olivier Langlois; Annie Laquerriere; Emmanuelle Lechap...; Caroline Le Guérinel; Pierre-Marie Levi...; Hugues Loiseau; Delphine Loussouarn; Claude-Alain Maurage; Philippe Menei; Marie Janette Mot...; Georges Noel; Fabrice Parker; Michel Peoc’h; Marc Polivka; Isabelle Quintin-...; Carole Ramirez; Damien Ricard; Pomone Richard; Valérie Rigau; Audrey Rousseau; Gwenaelle Runavot; Henri Sevestre; Marie Christine T...; Emmanuelle Uro-Coste; Fanny Burel-Vande...; Elodie Vauleon; Gabriel Viennet; Chiara Villa; Michel Wager
• Keywords: Exome

Anaplastic oligodendroglioma (AO) are rare primary brain tumours that generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosomes 1p/19q co-deletion an IDH mutation. Here we analysed 51 AO by whole-exome sequencing, identifying previously reported frequent somatic mutations in CIC FUBP1. We also identified recurrent TCF12 additional series of 83 AO. Overall, 7.5% mutated for TCF12, which encodes oligodendrocyte-related transcription factor. Eighty percent were either the bHLH domain, is important function as a factor, or frameshift leading to truncated this domain. show these compromise transcriptional activity associated more aggressive tumour type. Our analysis provides further insights into unique shared pathways driving