An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis

• DOI: 10.1038/ncomms8889
• Publication Date: 2015-08-05T09:51:55Z
• Authors: Sylvain Meunier; Maria Shvedunova; Nhuong Van Nguyen; Leonor Avila; Isabelle Vernos; Asifa Akhtar
• Keywords: Interphase

Abstract The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands genes. Here we uncover novel function the members in mitosis. As cell enters mitosis, KANSL1 and KANSL3 undergo marked relocalisation from chromatin to mitotic spindle. By stabilizing microtubule minus ends RanGTP-dependent manner, they are essential for spindle assembly chromosome segregation. Moreover, identify as minus-end-binding protein, revealing new class mitosis-specific minus-end regulators. adopting distinct functions interphase KANSL proteins provide link coordinate tasks faithful inheritance genome during different phases cycle.