Rescue of long-term memory after reconsolidation blockade

• DOI: 10.1038/ncomms8897
• Publication Date: 2015-08-04T09:56:48Z
• Authors: Simon Trent; Philip Barnes; Jeremy Hall; Kerrie L. Thomas
• Keywords: Retrograde amnesia; Extinction (optical mineralogy); Long-term memory; Blocking (statistics)

Abstract Memory reconsolidation is considered to be the process whereby stored memories become labile on recall, allowing updating. Blocking restabilization of a memory during held result in permanent amnesia. The targeted knockdown either Zif268 or Arc levels brain, and inhibition protein synthesis, after brief recall results non-recoverable retrograde amnesia, known as blockade. These experimental manipulations are seen key proof for existence reconsolidation. However, here we demonstrate that despite disrupting molecular correlates hippocampus, rodents still able recover contextual memories. Our challenge view separate instead suggest events activated initially at act constrain premature extinction.