Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy

• DOI: 10.1038/ncomms9045
• Publication Date: 2015-08-20T09:57:11Z
• Authors: Kevin Moreau; Ghita Ghislat; Warren Hochfeld; Maurizio Renna; Eszter Zavodszky; Gautam Runwal; Claudia Puri; Shirley Lee; Farah Siddiqi; Fiona M. Menzies; Brinda Ravikumar; David C. Rubinsztein
• Keywords: Annexin A2; Autophagosome

Abstract Autophagy is an important degradation pathway, which induced after starvation, where it buffers nutrient deprivation by recycling macromolecules in organisms from yeast to man. While the classical pathway mediating this response via mTOR inhibition, there are likely be additional pathways that support process. Here, we identify Annexin A2 as autophagy modulator regulates autophagosome formation enabling appropriate ATG9A trafficking endosomes autophagosomes actin. This process dependent on effectors ARP2 and Spire1. expression increases starvation cells mTOR-independent fashion. mediated Jun N-terminal kinase activation of c-Jun, which, turn, enhances trans-activation promoter. knockdown abrogates starvation-induced autophagy, while its overexpression induces autophagy. Hence, c-Jun-mediated transcriptional responses regulating levels.