Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

• DOI: 10.1038/ng.200
• Publication Date: 2008-08-01T18:00:22Z
• Authors: Robert R Graham; Chris Cotsapas; Leela Davies; Rachel Hackett; Christopher J Les...; Joanlise M Leon; Noel P Burtt; Candace Guiducci; Melissa Parkin; Casey Gates; Robert M Plenge; Timothy W Behrens; Joan E Wither; John D Rioux; Paul R Fortin; Deborah Cunningha...; Andrew K Wong; Timothy J Vyse; Mark J Daly; David Altshuler; Kathy L Moser; Patrick M Gaffney
• Keywords: Genome-wide Association Study; Genetic Association

Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10(-12), OR = 2.29). We also found evidence of two independent signals near TNFAIP3 associated with SLE, including one previously associated with rheumatoid arthritis (RA). These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA.