Rheumatoid arthritis association at 6q23

• DOI: 10.1038/ng.2007.32
• Publication Date: 2007-11-04T18:47:51Z
• Authors: Wendy Thomson; ; Anne Barton; Xiayi Ke; Steve Eyre; Anne Hinks; John Bowes; Rachelle Donn; Deborah Symmons; Samantha Hider; Ian N Bruce; Anthony G Wilson; Ioanna Marinou; Ann Morgan; Paul Emery; Angela Carter; Sophia Steer; Lynne Hocking; David M Reid; Paul Wordsworth; Pille Harrison; David Strachan; Jane Worthington
• Keywords: Genome-wide Association Study; SNP

The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3).