Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

• DOI: 10.1038/ng.218
• Publication Date: 2008-09-11T17:15:38Z
• Authors: Anne Barton; ; ; Wendy Thomson; Xiayi Ke; Steve Eyre; Anne Hinks; John Bowes; Darren Plant; Laura J Gibbons; Anthony G Wilson; Deborah E Bax; Ann W Morgan; Paul Emery; Sophia Steer; Lynne Hocking; David M Reid; Paul Wordsworth; Pille Harrison; Jane Worthington
• Keywords: Risk; Genetic Linkage; Chromosomes, Human, Pair 22; 610; Expression; genetics: Chromosomes, Human, Pair 22; Polymorphism, Single Nucleotide; 6Q23; Arthritis, Rheumatoid; 03 medical and health sciences; 616; Humans; Genetic Predisposition to Disease; genetics: Arthritis, Rheumatoid; 0303 health sciences; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 10; genetics: Polymorphism, Single Nucleotide; Linkage (Genetics); Chromosome Mapping; 1103 Clinical Sciences; genetics: Chromosomes, Human, Pair 12; genetics: Chromosomes, Human, Pair 10; Genome-wide Association; genetics: Genetic Predisposition to Disease; Case-Control Studies; Pathway

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.