Structure and function of a transcriptional network activated by the MAPK Hog1

• DOI: 10.1038/ng.235
• Publication Date: 2008-10-19T18:25:02Z
• Authors: Andrew P Capaldi; Tommy Kaplan; Ying Liu; Naomi Habib; Aviv Regev; Nir Friedman; Erin K O'Shea
• Keywords: Gene regulatory network; Budding yeast; Transcription

Cells regulate gene expression using a complex network of signaling pathways, transcription factors and promoters. To gain insight into the structure and function of these networks, we analyzed gene expression in single- and multiple-mutant strains to build a quantitative model of the Hog1 MAPK-dependent osmotic stress response in budding yeast. Our model reveals that the Hog1 and general stress (Msn2/4) pathways interact, at both the signaling and promoter level, to integrate information and create a context-dependent response. This study lays out a path to identifying and characterizing the role of signal integration and processing in other gene regulatory networks.