Lung cancer susceptibility locus at 5p15.33

Principal Component Analysis Lung Neoplasms Smoking Membrane Proteins Apoptosis Neoplasm Proteins 3. Good health 03 medical and health sciences 0302 clinical medicine Case-Control Studies Chromosomes, Human, Pair 5 Humans Genetic Predisposition to Disease Lung cancer Telomerase Genome-Wide Association Study
DOI: 10.1038/ng.254 Publication Date: 2008-11-02T19:19:02Z
ABSTRACT
We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the independent study series (P = 7 x 10(-5) and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.
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