Identification of a new prostate cancer susceptibility locus on chromosome 8q24

• DOI: 10.1038/ng.444
• Publication Date: 2009-09-20T18:13:53Z
• Authors: Meredith Yeager; Nilanjan Chatterjee; Julia Ciampa; Kevin B Jacobs; Jesus Gonzalez-Bo...; Richard B Hayes; Peter Kraft; Sholom Wacholder; Nick Orr; Sonja Berndt; Kai Yu; Amy Hutchinson; Zhaoming Wang; Laufey Amundadottir; Heather Spencer F...; Michael J Thun; W Ryan Diver; Demetrius Albanes; Jarmo Virtamo; Stephanie Weinstein; Fredrick R Schuma...; Geraldine Cancel-...; Olivier Cussenot; Antoine Valeri; Gerald L Andriole; E David Crawford; Christopher A Haiman; Brian Henderson; Laurence Kolonel; Loic Le Marchand; Afshan Siddiq; Elio Riboli; Timothy J Key; Rudolf Kaaks; William Isaacs; Sarah Isaacs; Kathleen E Wiley; Henrik Gronberg; Fredrik Wiklund; Pär Stattin; Jianfeng Xu; S Lilly Zheng; Jielin Sun; Lars J Vatten; Kristian Hveem; Merethe Kumle; Margaret Tucker; Daniela S Gerhard; Robert N Hoover; Joseph F Fraumeni; David J Hunter; Gilles Thomas; Stephen J Chanock
• Keywords: Genetic Markers; Male; 0301 basic medicine; Genotype; European Continental Ancestry Group; 610; Research Support; Polymorphism, Single Nucleotide; Chromosomes; White People; N.I.H.; 03 medical and health sciences; Risk Factors; 616; Journal Article; Humans; Polymorphism; Genome; Genome, Human; Extramural; Prostatic Neoplasms; Single Nucleotide; name=SDG 3 - Good Health and Well-being; 3. Good health; Pair 8; /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; Disease Susceptibility; Human; Chromosomes, Human, Pair 8; Genome-Wide Association Study

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.