Genetic loci influencing kidney function and chronic kidney disease

• DOI: 10.1038/ng.566
• Publication Date: 2010-04-11T18:05:51Z
• Authors: John C Chambers; Weihua Zhang; Graham M Lord; Pim van der Harst; Debbie A Lawlor; Joban S Sehmi; Daniel P Gale; Mark N Wass; Kourosh R Ahmadi; Stephan J L Bakker; Jacqui Beckmann; Henk J G Bilo; Murielle Bochud; Morris J Brown; Mark J Caulfield; John M C Connell; H Terence Cook; Ioana Cotlarciuc; George Davey Smith; Ranil de Silva; Guohong Deng; Olivier Devuyst; Lambert D Dikkeschei; Nada Dimkovic; Mark Dockrell; Anna Dominiczak; Shah Ebrahim; Thomas Eggermann; Martin Farrall; Luigi Ferrucci; Jurgen Floege; Nita G Forouhi; Ron T Gansevoort; Xijin Han; Bo Hedblad; Jaap J Homan van ...; Bouke G Hepkema; Maria Hernandez-F...; Elina Hypponen; Toby Johnson; Paul E de Jong; Nanne Kleefstra; Vasiliki Lagou; Marta Lapsley; Yun Li; Ruth J F Loos; Jian'an Luan; Karin Luttropp; Céline Maréchal; Olle Melander; Patricia B Munroe; Louise Nordfors; Afshin Parsa; Leena Peltonen; Brenda W Penninx; Esperanza Perucha; Anneli Pouta; Inga Prokopenko; Paul J Roderick; Aimo Ruokonen; Nilesh J Samani; Serena Sanna; Martin Schalling; David Schlessinger; Georg Schlieper; Marc A J Seelen; Alan R Shuldiner; Marketa Sjögren; Johannes H Smit; Harold Snieder; Nicole Soranzo; Timothy D Spector; Peter Stenvinkel; Michael J E Stern...; Ramasamyiyer Swam...; Toshiko Tanaka; Lielith J Ubink-V...; Manuela Uda; Peter Vollenweider; Chris Wallace; Dawn Waterworth; Klaus Zerres; Gerard Waeber; Nicholas J Wareham; Patrick H Maxwell; Mark I McCarthy; Marjo-Riitta Jarv...; Vincent Mooser; Goncalo R Abecasis; Liz Lightstone; James Scott; Gerjan Navis; Paul Elliott; Jaspal S Kooner
• Keywords: Genetic Markers; Genotype; Kidney; OCT2; Kidney Failure; 03 medical and health sciences; Genetic; Models; Humans; Genetic Predisposition to Disease; Chronic; Cystatin C; oct2; genetic predisposition to disease; 0303 health sciences; Models, Genetic; Genetic Variation; Biological Transport; 3. Good health; Europe; Gene Expression Regulation; Creatinine; genome-wide association studies; Kidney Failure, Chronic; chronic kidney disease; Genome-Wide Association Study; Glomerular Filtration Rate

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10 10 to 10 15). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 �� 10 5 and P = 3.6 �� 10 4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.