Long-term depression induced by sensory deprivation during cortical map plasticity in vivo
0301 basic medicine
0303 health sciences
Neuronal Plasticity
Patch-Clamp Techniques
Long-Term Synaptic Depression
Pyramidal Cells
Long-Term Potentiation
Excitatory Postsynaptic Potentials
Somatosensory Cortex
In Vitro Techniques
Rats
03 medical and health sciences
Vibrissae
Synapses
Animals
Rats, Long-Evans
Sensory Deprivation
DOI:
10.1038/nn1012
Publication Date:
2003-02-24T22:27:54Z
AUTHORS (3)
ABSTRACT
Cortical map plasticity is thought to involve long-term depression (LTD) of cortical synapses, but direct evidence for LTD during plasticity or learning in vivo is lacking. One putative role for LTD is in the reduction of cortical responsiveness to behaviorally irrelevant or unused sensory stimuli, a common feature of map plasticity. Here we show that whisker deprivation, a manipulation that drives map plasticity in rat somatosensory cortex (S1), induces detectable LTD-like depression at intracortical excitatory synapses between cortical layer 4 (L4) and L2/3 pyramidal neurons. This synaptic depression occluded further LTD, enhanced LTP, was column specific, and was driven in part by competition between active and inactive whiskers. The synaptic locus of LTD and these properties suggest that LTD underlies the reduction of cortical responses to deprived whiskers, a major component of S1 map plasticity.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (50)
CITATIONS (217)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....