Effect of anthelmintic treatment on leptin, adiponectin and leptin to adiponectin ratio: a randomized-controlled trial

• DOI: 10.1038/nutd.2017.37
• Publication Date: 2019-05-23T13:26:36Z
• Authors: D L Tahapary; K de Ruiter; I Martin; E A T Brienen; L van Lieshout; Y Djuardi; C C Djimandjaja; J J Houwing-Duist...; P Soewondo; E Sartono; T Supali; J W A Smit; M Yazdanbakhsh
• Keywords: Resistin

Abstract Emerging evidence suggests that helminths might confer protection against the development of type 2 diabetes. We aimed to assess role adipokines in mediating effect on insulin resistance. Serum samples were obtained from a randomized-controlled trial anthelmintic treatment an area endemic for soil-transmitted (STH), Flores Island, Indonesia. In STH-infected subjects, significantly increased ratio leptin adiponectin (treatment factor (95% confidence interval (CI)), P -value interaction: 1.20 (1.06–1.35), =0.010), which largely stemmed significant reduction (0.91 (0.85–0.98), =0.020) and trend increase level (1.10 (1.00–1.21), =0.119). No resistin was observed. This seemed contribute observed deworming resistance (IR) as adjustment attenuated IR 1.07 (1.01–1.14, =0.023) 1.05 (0.99–1.11, =0.075). Anthelmintic subjects increases may small part modest IR. Further studies will be needed changes adipokine levels host immune response metabolism.