Effect of anthelmintic treatment on leptin, adiponectin and leptin to adiponectin ratio: a randomized-controlled trial
Radboudumc 18: Healthcare improvement science RIHS: Radboud Institute for Health Sciences
Adult
Anthelmintics
Leptin
Male
0301 basic medicine
0303 health sciences
Short Communication
Helminthiasis
Middle Aged
Albendazole
3. Good health
Placebos
03 medical and health sciences
Diabetes Mellitus, Type 2
Double-Blind Method
Indonesia
Humans
Female
Adiponectin
Insulin Resistance
DOI:
10.1038/nutd.2017.37
Publication Date:
2019-05-23T13:26:36Z
AUTHORS (13)
ABSTRACT
AbstractEmerging evidence suggests that helminths might confer protection against the development of type 2 diabetes. We aimed to assess the role of adipokines in mediating the effect of helminths on insulin resistance. Serum samples were obtained from a randomized-controlled trial of anthelmintic treatment in an area endemic for soil-transmitted helminths (STH), Flores Island, Indonesia. In STH-infected subjects, anthelmintic treatment significantly increased the ratio of leptin to adiponectin (treatment effect factor (95% confidence interval (CI)), P-value for interaction: 1.20 (1.06–1.35), P=0.010), which largely stemmed from a significant reduction in adiponectin (0.91 (0.85–0.98), P=0.020) and a trend for an increase in leptin level (1.10 (1.00–1.21), P=0.119). No significant effect on resistin level was observed. This increase in leptin to adiponectin ratio seemed to contribute to the observed effect of deworming on increased insulin resistance (IR) as adjustment for leptin to adiponectin ratio attenuated the effect on IR from 1.07 (1.01–1.14, P=0.023) to 1.05 (0.99–1.11, P=0.075). Anthelmintic treatment in STH-infected subjects increases leptin to adiponectin ratio which may in small part contribute to the modest increase in IR. Further studies will be needed to assess the effect of the changes in adipokine levels on the host immune response and metabolism.
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