Increased Adipose Angiotensinogen Gene Expression in Human Obesity

• DOI: 10.1038/oby.2000.40
• Publication Date: 2008-04-15T11:39:09Z
• Authors: Vanessa van Harmelen; Parisa Ariapart; Johan Hoffstedt; Inger Lundkvist; Sven Bringman; Peter Arner
• Keywords: Adult; Male; 2. Zero hunger; Stomach; Angiotensinogen; Gene Expression; Middle Aged; Body Mass Index; 03 medical and health sciences; 0302 clinical medicine; Adipose Tissue; RNA, Ribosomal, 18S; Humans; Regression Analysis; Cholecystectomy; Obesity; RNA, Messenger; Aged

Abstract Objective: Adipose angiotensinogen has been suggested as a stimulator of adipose tissue growth and development. Therefore, the association subcutaneous gene expression with human obesity was studied. Research Methods Procedures: The study group consisted 17 men, undergoing either gastric banding for or elective laparoscopic cholecystectomy (7 obese, 10 non‐obese men; body mass index 22 to 51 kg/m 2 ; age 26 68 years). Subcutaneous mRNA 18S ribosomal RNA (reference gene) levels were measured using competitive quantitative reverse transcriptase‐polymerase chain reaction. Results: about two times increased in obesity. rRNA did not differ between groups. Body weight correlated independently positively after adjusting differences height. Discussion: is elevated men.