Topiramate Reduces Energy and Fat Gains in Lean (Fa/?) and Obese (fa/fa) Zucker Rats

• DOI: 10.1038/oby.2000.84
• Publication Date: 2008-04-15T11:55:17Z
• Authors: Frédéric Picard; Yves Deshaies; Josée Lalonde; Pierre Samson; Denis Richard
• Keywords: Hyperinsulinemia

Abstract Objective: This study examined the effects of topiramate (TPM), a novel neurotherapeutic agent reported to reduce body weight in humans, on components energy balance female Zucker rats. Research Methods and Procedures: A 2 × 3 factorial experiment was performed which two cohorts rats differing their phenotype (phenotype: lean, Fa/? ; obese, fa/fa ) were each divided into three groups defined by dose TPM administered (dose: 0, vehicle; 15, 15 mg/kg; 60, 60 mg/kg). Results: The reduction gain induced both lean obese reflected decrease total gain, more evident than Whereas administration did not influence intake digestible rats, it food animals. In but apparent expenditure (as calculated difference between gain) higher treated with animals vehicle. low decreased fat (with emphasis subcutaneous fat) without affecting protein whereas high drug gains. muscle depot weights representative global whole energetic efficiency (energy gain/energy intake) after treatment. independently reduced hyperinsulinemia alter insulinemia Discussion: present results provide sound evidence for ability gains through reducing