Association of Cholecystokinin 1 Receptor and β3‐Adrenergic Receptor Polymorphisms with Midlife Weight Gain

• DOI: 10.1038/oby.2004.152
• Publication Date: 2008-04-21T09:21:54Z
• Authors: Michiko Koda; Fujiko Ando; Naoakira Niino; Hiroshi Shimokata; Kyoko Miyasaka; Akihiro Funakoshi
• Keywords: Adult; Male; Aging; Sex Characteristics; Polymorphism, Genetic; Genotype; Middle Aged; Weight Gain; 03 medical and health sciences; Logistic Models; 0302 clinical medicine; Receptors, Adrenergic, beta-3; Odds Ratio; Humans; Female; Receptors, Cholecystokinin; Longitudinal Studies

Abstract We investigated the relationship of polymorphisms in cholecystokinin 1 receptor [ CCK1R ; G to T (n‐128), A (n‐81)] and β 3 ‐ adrenergic (β AR Trp64Arg) with midlife weight gain. The participants were 1012 Japanese men women (40 59 years age). Their at 18 old was obtained from a questionnaire. Weight change defined as current minus old. Subjects grouped into four categories by these genotypes: W/W = noncarriers, W/H Arg 64 carriers , H/W (n‐128) or (n‐81) H/H carriers. In men, interaction between significant (two‐way ANOVA, p < 0.05), but neither nor individually associated group showed higher possibility gain 10 kg more compared men. odds ratio for (≥10 kg) 2.54 (95% confidence interval: 1.50 4.30) W/W. women, main effect significant. These results suggest that combination is contributing factor