Gene or Size: Metabolic Rate and Body Temperature in Obese Growth Hormone‐Deficient Dwarf Mice

• DOI: 10.1038/oby.2004.188
• Publication Date: 2008-04-21T09:25:09Z
• Authors: Carola W.E. Meyer; Martin Klingenspor; Jan Rozman; Gerhard Heldmaier
• Keywords: 0301 basic medicine; 2. Zero hunger; Mice, Inbred C3H; Rest; Calorimetry, Indirect; Body Temperature; Mice; 03 medical and health sciences; Oxygen Consumption; Body Composition; Animals; Body Size; Basal Metabolism; Obesity; Dwarfism, Pituitary; Energy Metabolism

Abstract Objective : SMA1 mice carry a missense mutation in the growth hormone gene that leads to semidominant dwarfism and obesity. In this study, basic thermal metabolic properties of were examined detect alterations can support accretion excess fat. Research Methods Procedures Basal resting rates (RMRs) wild‐type ( sma1 /+ sma1/sma1 ) determined by indirect calorimetry. Body temperature (T b was recorded using intraperitoneally implanted temperature‐sensitive transmitters, body composition DXA. Results have proportionally lower basal rates, higher mass (BM)‐specific RMRs, critical temperature, display decrease T 0.4 °C 0.9 . Discussion The analysis effects on BM energy expenditure mouse mutants must consider appropriate allometric relationship between rate. With exception , all observed reflect reduced size.