Physiological Evidence for the Involvement of Peptide YY in the Regulation of Energy Homeostasis in Humans

• DOI: 10.1038/oby.2006.180
• Publication Date: 2008-04-23T14:27:09Z
• Authors: Yan Guo; Lijun Ma; Pablo J. Enriori; Juraj Koska; Paul W. Franks; Thomas Brookshire; Michael A. Cowley; Arline D. Salbe; Angelo DelParigi; P. Antonio Tataranni
• Keywords: Peptide YY; Respiratory quotient; Energy homeostasis; Homeostasis

Abstract Objective: To explore the potential role of endogenous peptide YY (PYY) in long‐term regulation body weight and energy homeostasis. Research Methods Procedures: Fasting postprandial plasma PYY concentrations were measured after an overnight fast 30 to 180 minutes a standardized meal 29 (21 men/8 women) non‐diabetic subjects, 16 whom had follow‐up visit 10.8 ± 1.4 months later. Ratings hunger satiety collected using visual analog scales. Resting metabolic rate (RMR) (15‐hour RMR) respiratory quotient (RQ) assessed chamber. Results: negatively correlated with various markers adiposity associated 15‐hour RMR ( r = −0.46, p 0.01). Postprandial changes (area under curve) positively ratings 0.47, The maximal achieved (peak PYY) 24‐hour RQ −0.41, 0.03). Prospectively, peak −0.58, Discussion: Our data indicate that may be involved weight. It seems this effect was not exclusively driven by modulation food intake but also control expenditure lipid metabolism.