Hepatic Expression of Cell Death–inducing DFFA‐like Effector C in Obese Subjects Is Reduced by Marked Weight Loss

• DOI: 10.1038/oby.2009.236
• Publication Date: 2009-08-06T14:39:50Z
• Authors: Angela M. Hall; Elizabeth M. Brunt; Samuel Klein; Brian N. Finck
• Keywords: Male; 0301 basic medicine; 2. Zero hunger; 0303 health sciences; Time Factors; Gastric Bypass; Down-Regulation; Proteins; Body Mass Index; 03 medical and health sciences; Treatment Outcome; Liver; Weight Loss; Humans; Female; Obesity; Apoptosis Regulatory Proteins; Adiposity

The hepatic expression of the cell death-inducing DNA fragmentation factor A-like effector family (CIDEA, CIDEB, and CIDEC) genes is markedly upregulated in mouse models obesity. We evaluated CIDE liver obese human subjects undergoing gastric bypass surgery (GBS), at time again 1 year later when had lost 37.6 +/- 1.4% their initial body weight. At GBS, CIDEA (r(2) = 0.20, P 0.04) CIDEC 0.32, 0.01) was strongly correlated with BMI, whereas CIDEB not 0.01, 0.81). One after surgery, declined over 60% (P 0.02), did change 0.20). These data demonstrate that, consistent previous studies conducted rodents, CIDEC, but increased humans. Moreover, downregulated by marked weight loss.