Altered Default Network Activity in Obesity

• DOI: 10.1038/oby.2011.119
• Publication Date: 2011-06-03T04:22:33Z
• Authors: Jason R. Tregellas; Korey P. Wylie; Donald C. Rojas; Jody Tanabe; Jesse Martin; Eugene Kronberg; Dietmar Cordes; Marc‐Andre Cornier
• Keywords: Posterior cingulate; Dysfunctional family

The regulation of energy intake is a complex process involving the integration homeostatic signals and both internal external sensory inputs. To better understand neurobiology this how it may be dysfunctional in obesity, study examined activity brain's "default network" reduced-obese (RO) as compared to lean individuals. default network group functionally connected brain regions thought play an important role internally directed cognitive interplay between processing. Functional magnetic resonance imaging was performed 24 18 RO individuals fasted state after 2 days eucaloric 30% overfeeding counterbalanced design. Scanning while subjects passively viewed images food nonfood objects. Independent component analysis used identify component. In state, greater observed lateral inferior parietal posterior cingulate cortices. Activity positively correlated with appetite. Overfeeding resulted increased but not These findings suggest that function network, major contributor intrinsic neuronal activity, altered obesity and/or obese-prone Future studies network's its relationship other networks improve our understanding mechanisms treatment obesity.