Estrogen receptor β promotes bladder cancer growth and invasion via alteration of miR-92a/DAB2IP signals

• DOI: 10.1038/s12276-018-0155-5
• Publication Date: 2018-11-20T06:28:29Z
• Authors: Zhenyu Ou; Yongjie Wang; Jinbo Chen; Le Tao; Li Zuo; Deepak Sahasrabudhe; Jean Joseph; Long Wang; Shuyuan Yeh
• Keywords: Hormone response element; Estrogen receptor alpha

Although early studies suggested that bladder cancer (BCa) is more prevalent in men than women, muscle-invasive rates are higher women men, suggesting sex hormones might play important roles different stages of BCa progression. In this work, we found estrogen receptor beta (ERβ) could increase cell proliferation and invasion via alteration miR-92a-mediated DAB2IP (DOC-2⁄DAB2 interacting protein) signals blocking miR-92a expression with an inhibitor partially reverse ERβ-enhanced growth invasion. Further mechanism dissection ERβ at the transcriptional level binding to estrogen-response-element (ERE) on 5′ promoter region its host gene C13orf25. The up-regulated decrease tumor suppressor site located 3′ UTR. Preclinical using vivo mouse model also confirmed targeting newly identified ERβ/miR-92a/DAB2IP signal pathway small molecules suppress Together, these results aid development new therapies ERβ-mediated better Blocking effects female hormone may survival rate (BCa). common tumors likely invade neighboring tissues women. Sex their receptors, which known affect progression other cancers, a key role. A team led by Shuyuan Yeh University Rochester Medical Center, USA, Wang Long Central South University, Changsha, China, investigated role plays BCa. They reducing levels made cells less invasive. investigation revealed way block signaling, tissue model. Understanding signaling help develop treatments for