Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer

• DOI: 10.1038/s12276-019-0295-2
• Publication Date: 2019-08-09T10:03:05Z
• Authors: Dong Ha Kim; HyeongRyul Kim; Yun Jung Choi; Seon Ye Kim; Jung-Eun Lee; Ki Jung Sung; Young Hoon Sung; Chan-Gi Pack; Min-kyo Jung; Buhm Han; Kunhee Kim; Woo Sung Kim; Soo Jeong Nam; Chang-Min Choi; Miyong Yun; Jae Cheol Lee; Jin Kyung Rho
• Keywords: Immune escape

Abstract Programmed cell death protein-1/programmed ligand-1 (PD-1/PD-L1) pathway blockade is a promising new cancer therapy. Although PD-1/PD-L1 treatment has yielded clinical benefits in several types of cancer, further studies are required to clarify predictive biomarkers for drug efficacy and understand the fundamental mechanism interaction between host tumor cells. Here, we show that exosomes derived from lung cells express PD-L1 play role immune escape by reducing T-cell activity promoting growth. The abundance on represented quantity expression surfaces. Exosomes containing inhibited interferon-gamma (IFN-γ) secretion Jurkat T IFN-γ was restored knockout or masking exosomes. Both forced without with enhanced growth vivo. present isolated plasma patients non-small its correlated positivity tissues. can impair functions cytokine production inducing apoptosis CD8 + Our findings indicate tumor-derived expressing may be an important mediator escape.