TLR7-dependent eosinophil degranulation links psoriatic skin inflammation to small intestinal inflammatory changes in mice

• DOI: 10.1038/s12276-024-01225-y
• Publication Date: 2024-05-01T01:02:00Z
• Authors: Hee Joo Kim; Jinsun Jang; Kunhee Na; Eun-Hui Lee; Hyeon-Jung Gu; Yoon Hee Lim; Seul-A Joo; Seung Eun Baek; Joo-Young Roh; Han-Joo Maeng; Yun Hak Kim; Young-Jae Lee; Byung-Chul Oh; YunJae Jung
• Keywords: TLR7

Recent evidence of gut microbiota dysbiosis in the context psoriasis and increased cooccurrence inflammatory bowel disease suggest a close relationship between skin immune responses. Using mouse model induced by Toll-like receptor (TLR) 7 ligand imiquimod, we found that psoriatic dermatitis was accompanied changes small intestine associated with eosinophil degranulation, which impaired intestinal barrier integrity. Inflammatory responses were mice prone to degranulation. Caco-2 human epithelial cells treated media containing granule proteins exhibited signs inflammation damage. Imiquimod-induced attenuated eosinophil-deficient mice, this attenuation counteracted transfer eosinophils. Imiquimod levels distribution eosinophils positively correlated intestine. TLR7-deficient did not exhibit degranulation but following imiquimod administration. These results TLR7-dependent bidirectional skin-to-gut communication occurs can accelerate psoriasis.