Mandible-derived extracellular vesicles regulate early tooth development in miniature swine via targeting KDM2B

• DOI: 10.1038/s41368-025-00348-w
• Publication Date: 2025-04-27T08:34:24Z
• Authors: Ye Li; Meng Sun; Yi Ding; Ang Li
• Keywords: Mandible (arthropod mouthpart); Demethylase; Extracellular vesicles

Abstract Tissue interactions play a crucial role in tooth development. Notably, extracellular vesicle-mediated between the mandible and germ are considered essential. Here, we revealed that vesicles could modulate proliferation differentiation of dental mesenchymal cells by regulating histone demethylase KDM2B. Further investigation showed derived deliver miR-206 to KDM2B, thereby An animal study demonstrated miR-206/KDM2B pathway affected morphogenesis mineralization after eight weeks subcutaneous transplantation nude mice. In conclusion, this suggested played critical mineralization, which be potential therapeutic target for abnormal development an alternative model regeneration.