Image-based prenatal predictors correlate with postnatal survival, extracorporeal life support use, and defect size in left congenital diaphragmatic hernia

• DOI: 10.1038/s41372-022-01357-x
• Publication Date: 2022-02-28T18:04:09Z
• Authors: Erin E. Perrone; Monita Karmakar; Pamela A. Lally; Sukyung Chung; Florian Kipfmueller; Francesco Morini; Ryan Phillips; Krisa P. Van Meurs; Matthew T. Harting; George B. Mychaliska; Kevin P. Lally
• Keywords: No keywords available; Extracorporeal Membrane Oxygenation; Pregnancy; Humans; Female; Hernias, Diaphragmatic, Congenital; Magnetic Resonance Imaging; Ultrasonography, Prenatal; Retrospective Studies

To evaluate the association between prenatal imaging predictors of patients with left-sided congenital diaphragmatic hernia (LCDH) and postnatal outcomes.CDH study group data were reviewed for LCDH infants born 2015-2019. Prenatal ultrasound (US) and magnetic resonance imaging (MRI) data were collected and correlated with postnatal information including CDHSG defect size (A through D or non-repair (NR)).In total, 929 LCDH patients were included. Both US and MRI imaging predictors correlated with postnatal survival (72.2%) and ECLS use (29.6%). Logistic regression models confirmed increased survival and decreased ECLS use with larger values for all predictors. Importantly, all prenatal values evaluated showed no significant difference between defect size D and NR patients.This is the largest cohort of LCDH patients and demonstrates that prenatal imaging factors correlate with postnatal outcomes and confirms that patients in the non-repair group are prenatally similar to type D defects.