Hybrid magnetic resonance and optoacoustic tomography (MROT) for preclinical neuroimaging

• DOI: 10.1038/s41377-022-01026-w
• Publication Date: 2022-11-24T19:02:46Z
• Authors: Zhenyue Chen; Irmak Gezginer; Mark-Aurel Augath; Wuwei Ren; Yu-Hang Liu; Ruiqing Ni; Xosé Luís Deán-Ben; Daniel Razansky
• Keywords: Functional Imaging

Abstract Multi-modal imaging is essential for advancing our understanding of brain function and unraveling pathophysiological processes underlying neurological psychiatric disorders. Magnetic resonance (MR) optoacoustic (OA) have been shown to provide highly complementary contrasts capabilities preclinical neuroimaging. True integration between these modalities can thus offer unprecedented studying the rodent in action. We report on a hybrid magnetic tomography (MROT) system concurrent noninvasive structural functional mouse brain. Volumetric OA was designed as an insert into high-field MR scanner by integrating customized MR-compatible spherical transducer array, illumination module, dedicated radiofrequency coil. A tailored data processing pipeline has developed mitigate signal crosstalk accurately register image volumes acquired with T1-weighted, angiography, blood oxygenation level-dependent (BOLD) sequences onto corresponding vascular recorded modality. demonstrate acquisition dual-mode anatomical angiographic images scanner, well real-time readings multiple hemodynamic parameters from animals subjected stress. Our approach combines molecular advantages superb soft-tissue contrast MR, further providing excellent platform cross-validation two modalities.