Violent aggression predicted by multiple pre-adult environmental hits

• DOI: 10.1038/s41380-018-0043-3
• Publication Date: 2018-05-23T09:21:12Z
• Authors: Marina Mitjans; Jan Seidel; Martin Begemann; Fabian Bockhop; Jorge Moya-Higueras; Vikas Bansal; Janina Wesolowski; Anna Seelbach; Manuel Ignacio Ib...; Fatka Kovacevic; Oguzhan Duvar; Lourdes Fañanás; Hannah-Ulrike Wolf; Generós Ortet; Peter Zwanzger; Verena Klein; Ina Lange; Andreas Tänzer; Manuela Dudeck; Lars Penke; Ludger Tebartz va...; Robert A. Bittner; Richard Schmidmeier; Roland Freese; Rüdiger Müller-Is...; Jens Wiltfang; Thomas Bliesener; Stefan Bonn; Luise Poustka; Jürgen L. Müller; Bárbara Arias; Hannelore Ehrenreich
• Keywords: Adult; Male; 0301 basic medicine; Adolescent; 610; Histone Deacetylase 1; Violence; Psychische Störung; Article; Impacte ambiental; Epigenesis, Genetic; Environmental impact; 03 medical and health sciences; 5. Gender equality; Adverse Childhood Experiences; Risk Factors; Odds Ratio; Humans; Exposure to Violence; Biomarker; Neurowissenschaften; 3. Good health; Aggression; Mental illness; Schizophrenia; Esquizofrènia; Female; Malalties mentals

Early exposure to negative environmental impact shapes individual behavior and potentially contributes any mental disease. We reported previously that accumulated risk markedly decreases age at schizophrenia onset. Follow-up of matched extreme group individuals (≤1 vs. ≥3 risks) unexpectedly revealed high-risk subjects had >5 times greater probability forensic hospitalization. In line with longstanding sociological theories, we hypothesized accumulation before adulthood induces violent aggression criminal conduct, independent illness. determined in 6 cohorts (4 2 general population samples) pre-adult exposure, comprising urbanicity, migration, physical sexual abuse as primary, cannabis or alcohol secondary hits. All single hits by themselves were marginally associated higher aggression. Most strikingly, however, their strongly predicted (odds ratio 10.5). An epigenome-wide association scan detect differential methylation blood-derived DNA selected yielded overall results. Conversely, determination peripheral blood mononuclear cells histone-deacetylase1 mRNA 'umbrella mediator' epigenetic processes an increase the group, suggesting lasting alterations. Together, provide sound evidence a disease-independent unfortunate relationship between well-defined aggression, calling for more efficient prevention.