Polyunsaturated fatty acids metabolism, purine metabolism and inosine as potential independent diagnostic biomarkers for major depressive disorder in children and adolescents

• DOI: 10.1038/s41380-018-0047-z
• Publication Date: 2018-04-20T11:05:23Z
• Authors: Xinyu Zhou; Lanxiang Liu; Xinghui Lan; David Cohen; Yuqing Zhang; Arun V Ravindran; Shuai Yuan; Peng Zheng; David Coghill; Lining Yang; Sarah E Hetrick; Xiaofeng Jiang; Jean-Jacques Beno...; Andrea Cipriani; Peng Xie
• Keywords: Inosine; Pathophysiology

Major depressive disorder (MDD) in children and adolescents is a recurrent disabling condition globally but its pathophysiology remains poorly elucidated there are limited effective treatments available. We performed metabolic profiling of plasma samples based on ultra-high-performance liquid chromatography equipped with quadrupole time-offlight mass spectrometry to explore the potential biomarkers depression MDD. identified several perturbed pathways, including fatty acid metabolism—particularly polyunsaturated acids metabolism, purine metabolism—that were associated MDD these young patients. In addition, inosine was shown as independent diagnostic biomarker for MDD, achieving an area under ROC curve 0.999 discriminating drug-naive patients 0.866 drug-treated from healthy controls. Moreover, we found evidence differences that adult specifically tryptophan metabolism. Through metabolomic analysis, have links between framework perturbations child adolescent