Disrupted intrinsic functional brain topology in patients with major depressive disorder

• DOI: 10.1038/s41380-021-01247-2
• Publication Date: 2021-08-12T14:03:15Z
• Authors: Hong Yang; Xiao Chen; Zuo-Bing Chen; Le Li; Xue-Ying Li; Francisco Xavier ...; Tong-Jian Bai; Qi-Jing Bo; Jun Cao; Zhi-Kai Chang; Guan-Mao Chen; Ning-Xuan Chen; Wei Chen; Chang Cheng; Yu-Qi Cheng; Xi-Long Cui; Jia Duan; Yiru Fang; Qi-Yong Gong; Wen-Bin Guo; Zheng-Hua Hou; Lan Hu; Li Kuang; Feng Li; Hui-Xian Li; Kai-Ming Li; Tao Li; Yan-Song Liu; Zhe-Ning Liu; Yi-Cheng Long; Bin Lu; Qing-Hua Luo; Hua-Qing Meng; Daihui Peng; Hai-Tang Qiu; Jiang Qiu; Yue-Di Shen; Yu-Shu Shi; Tian-Mei Si; Yan-Qing Tang; Chuan-Yue Wang; Fei Wang; Kai Wang; Li Wang; Xiang Wang; Ying Wang; Yu-Wei Wang; Xiao-Ping Wu; Xin-Ran Wu; Chun-Ming Xie; Guang-Rong Xie; Hai-Yan Xie; Peng Xie; Xiu-Feng Xu; Jian Yang; Jia-Shu Yao; Shu-Qiao Yao; Ying-Ying Yin; Yong-Gui Yuan; Yu-Feng Zang; Ai-Xia Zhang; Hong Zhang; Ke-Rang Zhang; Lei Zhang; Zhi-Jun Zhang; Jing-Ping Zhao; Rubai Zhou; Yi-Ting Zhou; Jun-Juan Zhu; Zhi-Chen Zhu; Chao-Jie Zou; Xi-Nian Zuo; Chao-Gan Yan
• Keywords: Robustness

Abstract Aberrant topological organization of whole-brain networks has been inconsistently reported in studies patients with major depressive disorder (MDD), reflecting limited sample sizes. To address this issue, we utilized a big data MDD from the REST-meta-MDD Project, including 821 and 765 normal controls (NCs) 16 sites. Using Dosenbach 160 node atlas, examined functional extracted features (e.g., global local efficiency, nodal degree) using graph theory-based methods. Linear mixed-effect models were used for group comparisons to control site variability; robustness results was confirmed multiple parameters, different definitions, several head motion strategies applied). We found decreased efficiency compared NCs. At level, characterized by degrees somatomotor network (SMN), dorsal attention (DAN) visual (VN) default mode (DMN), SMN, DAN, VN. These differences mostly driven recurrent patients, rather than first-episode drug naive (FEDN) MDD. In highly powered multisite study, observed disrupted architecture brain MDD, suggesting both locally globally networks.