Eosinophil-derived chemokine (hCCL15/23, mCCL6) interacts with CCR1 to promote eosinophilic airway inflammation

• DOI: 10.1038/s41392-021-00482-x
• Publication Date: 2021-02-28T00:35:02Z
• Authors: Xufei Du; Fei Li; Chao Zhang; Na Li; Huaqiong Huang; Zhehua Shao; Min Zhang; Xueqin Zhan; Yicheng He; Zhenyu Ju; Wen Li; Zhihua Chen; Songmin Ying; Huahao Shen
• Keywords: CCR1; CC chemokine receptors; CCL13; Allergic Inflammation

Abstract Eosinophils are terminally differentiated cells derived from hematopoietic stem (HSCs) in the bone marrow. Several studies have confirmed effective roles of eosinophils asthmatic airway pathogenesis. However, their regulatory functions not been well elucidated. Here, increased C-C chemokine ligand 6 (CCL6) mice and human orthologs CCL15 CCL23 that highly expressed asthma patients described, which mainly eosinophils. Using Ccl6 knockout mice, further revealed CCL6-dependent allergic inflammation committed eosinophilia marrow following ovalbumin (OVA) challenge identified a CCL6-CCR1 axis (HSCs). Eosinophil differentiation were remarkably decreased by specific CCR1 antagonist BX471. Thus, study identifies is involved crosstalk between HSCs during development inflammation, also reveals potential therapeutic strategy for targeting G protein-coupled receptors (GPCRs) future clinical treatment asthma.