POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy

• DOI: 10.1038/s41392-022-00900-8
• Publication Date: 2022-03-28T00:02:27Z
• Authors: Changyu Cao; Tingbo Zhang; Nan Yang; Xianghong Niu; Zhaobo Zhou; Jinlan Wang; Dongliang Yang; Peng Chen; Liping Zhong; Xiaochen Dong; Yongxiang Zhao
• Keywords: :Bioengineering [Engineering]; Methicillin-Resistant Staphylococcus aureus; Bacteria; QH301-705.5; R; Hydrogen-Ion Concentration; 01 natural sciences; Article; Gold Nanoparticle; Hydroxyapatite; Anti-Bacterial Agents; 0104 chemical sciences; 3. Good health; Photochemotherapy; Medicine; Biology (General); Peroxidase

Abstract The current feasibility of nanocatalysts in clinical anti-infection therapy, especially for drug-resistant bacteria infection is extremely restrained because the insufficient reactive oxygen generation. Herein, a novel Ag/Bi 2 MoO 6 (Ag/BMO) nanozyme optimized by charge separation engineering with photoactivated sustainable peroxidase-mimicking activities and NIR-II photodynamic performance was synthesized solvothermal reaction photoreduction. Ag/BMO held satisfactory bactericidal against methicillin-resistant Staphylococcus aureus (MRSA) (~99.9%). excellent antibacterial NPs ascribed to corporation peroxidase-like activity, behavior, acidity-enhanced release Ag + . As revealed theoretical calculations, introduction BMO made it easier separate photo-triggered electron-hole pairs ROS production. And conduction valence band potentials were favorable reduction O ·O − Under 1064 nm laser irradiation, electron transfer beneficial reversible change Mo 5+ /Mo 6+ , further improving catalytic activity based on Russell mechanism. In vivo, exhibited promising therapeutic effects towards MRSA-infected wounds. This study enriches research proves that nanozymes can be rationally strategy.