Aberrant salience network functional connectivity in auditory verbal hallucinations: a first episode psychosis sample

• DOI: 10.1038/s41398-018-0118-6
• Publication Date: 2018-04-04T02:13:47Z
• Authors: Pavan Kumar Malli...; Paris Alexandros ...; Thomas Frederick ...; Kareen Heinze; Renate LEP Reniers; Matthew R. Broome; Baldeep Farmah; Femi Oyebode; Stephen J Wood; Rachel Upthegrove
• Keywords: Posterior cingulate; Auditory hallucination; Functional Imaging

Auditory verbal hallucinations (AVH) often lead to distress and functional disability, are frequently associated with psychotic illness. Previously both state trait magnetic resonance imaging (MRI) studies of AVH have identified activity in brain regions involving auditory processing, language, memory areas default mode network (DMN) salience (SN). Current evidence is clouded by research mainly participants on long-term medication, chronic illness choice seed made 'a priori'. Thus, the aim this study was elucidate intrinsic connectivity patients presenting first episode psychosis (FEP). Resting MRI data were available from 18 FEP patients, 9 whom also experienced sufficient duration scanner had symptom capture (sc fMRI), together healthy controls. Symptom results used accurately identify specific active during AVH; including superior temporal cortex, insula, precuneus, posterior cingulate parahippocampal complex. Using these as regions, showed increased resting sb-FC between parts SN DMN cerebellum, but reduced claustrum compared controls.It possible that aberrant within complex may be directly linked impaired appraisal internal generation. Furthermore, decreased insula compensatory over involved DMN, language memory, potentially related individual content when they occur.