Increased functional connectivity of the posterior cingulate cortex with the lateral orbitofrontal cortex in depression

• DOI: 10.1038/s41398-018-0139-1
• Publication Date: 2018-04-19T15:54:14Z
• Authors: Wei Cheng; Edmund T. Rolls; Jiang Qiu; Xiongfei Xie; Dongtao Wei; Chu-Chung Huang; Albert C. Yang; Shih-Jen Tsai; Qi Li; Jie Meng; Ching-Po Lin; Peng Xie; Jianfeng Feng
• Keywords: Orbitofrontal cortex; Posterior cingulate; Depression; Cingulate cortex

To analyze the functioning of posterior cingulate cortex (PCC) in depression, we performed first fully voxel-level resting state functional-connectivity neuroimaging analysis depression PCC, with 336 patients major depressive disorder and 350 controls. Voxels PCC had significantly increased functional connectivity lateral orbitofrontal cortex, a region implicated non-reward which is thereby depression. In receiving medication, between was decreased back towards that controls, it shown has high parahippocampal regions are involved memory. The findings support theory system effects on memory systems, contribute to rumination about sad memories events These new provide evidence key target ameliorate cortex.