ADHD-like behaviors caused by inactivation of a transcription factor controlling the balance of inhibitory and excitatory neuron development in the mouse anterior brainstem

• DOI: 10.1038/s41398-020-01033-8
• Publication Date: 2020-10-21T11:02:49Z
• Authors: Francesca Morello; Vootele Voikar; Pihla Parkkinen; Anne Panhelainen; Marko Rosenholm; Aki Makkonen; Tomi Rantamäki; Petteri Piepponen; Teemu Aitta-aho; Juha Partanen
• Keywords: Neurochemical

Abstract The neural circuits regulating motivation and movement include midbrain dopaminergic neurons associated inhibitory GABAergic excitatory glutamatergic in the anterior brainstem. Differentiation of specific subtypes mouse embryonic brainstem is controlled by a transcription factor Tal1 . This study characterizes behavioral neurochemical changes caused absence function. cko mutant mice are hyperactive, impulsive, hypersensitive to reward, have learning deficits habituation defect novel environment. Only minor their system were detected. Amphetamine induced striatal dopamine release amphetamine place preference normal mice. Increased signaling failed stimulate locomotor activity mice, but instead alleviated hyperactivity. Altogether, recapitulate many features attention hyperactivity disorders, suggesting role for regulated developmental pathways structures control movement.