Polygenic risk score, healthy lifestyles, and risk of incident depression

• DOI: 10.1038/s41398-021-01306-w
• Publication Date: 2021-03-29T07:02:36Z
• Authors: Zhi Cao; Hongxi Yang; Yixuan Ye; Yuan Zhang; Shu Li; Hongyu Zhao; Yaogang Wang
• Keywords: Depression; Polygenic risk score; Lower risk

Abstract Genetic factors increase the risk of depression, but extent to which this can be offset by modifiable lifestyle is unknown. We investigated whether a combination healthy lifestyles associated with lower depression regardless genetic risk. Data were obtained from UK Biobank and consisted 339,767 participants (37–73 years old) without between 2006 2010. was categorized as low, intermediate, or high according polygenic score for depression. A factors—including no current smoking, regular physical activity, diet, moderate alcohol intake body mass index <30 kg/m 2 —was into favorable, unfavorable lifestyles. The 22% higher among those at compared low (HR = 1.22, 95% CI: 1.14–1.30). Participants had more than two-fold incident favorable 2.18, 1.84–2.58). There significant interaction ( P 0.69). Among risk, nearly 50% relative an 0.51, 0.43–0.60). concluded that independently Adherence may