Gut microbiota link dietary fiber intake and short-chain fatty acid metabolism with eating behavior

• DOI: 10.1038/s41398-021-01620-3
• Publication Date: 2021-10-01T11:02:54Z
• Authors: Evelyn Medawar; Sven-Bastiaan Haange; Ulrike Rolle-Kamp...; Beatrice Engelmann; Arne Dietrich; Ronja Thieleking; Charlotte Wiegank; Charlotte Fries; Annette Horstmann; Arno Villringer; Martin von Bergen; Wiebke Fenske; A. Veronica Witte
• Keywords: Ruminococcus; Roseburia; Clostridiales

Abstract The gut microbiome has been speculated to modulate feeding behavior through multiple factors, including short-chain fatty acids (SCFA). Evidence on this relationship in humans is however lacking. We aimed explore if specific bacterial genera relate eating behavior, diet, and SCFA adults. Moreover, we tested whether eating-related microbiota treatment success patients after Roux-en-Y gastric bypass (RYGB). Anthropometrics, dietary fiber intake, 16S-rRNA-derived microbiota, fecal serum were correlated young overweight adults ( n = 27 (9 F), 21–36 years, BMI 25–31 kg/m 2 ). Correlated compared RYGB 23 (16 41–70 25–62 ) control 17 (11 26–69 25–48 In adults, 7 bacteria genera, i.e., Alistipes, Blautia, Clostridiales cluster XVIII, Gemmiger, Roseburia, Ruminococcus, Streptococcus, with healthier while 5 IV XIVb, Collinsella, Fusicatenibacter, Parabacteroides, unhealthier (all | r > 0.4, FDR-corrected p < 0.05). Some of these Parabacteroides related intake SCFA, weight status response overweight/obese patients. exploratory analysis, particularly associated two small, independent well-characterized cross-sectional samples. These preliminary findings suggest groups presumably beneficial unfavorable that status, indicate metabolism may modify relationships. Larger interventional studies are needed distinguish correlation from causation.