Characterizing the tumor microenvironment at the single-cell level reveals a novel immune evasion mechanism in osteosarcoma

• DOI: 10.1038/s41413-022-00237-6
• Publication Date: 2023-01-03T05:05:54Z
• Authors: Weijian Liu; Hongzhi Hu; Zengwu Shao; Xiao Lv; Zhicai Zhang; Xiangtian Deng; Qingcheng Song; Yong Han; Tao Guo; Liming Xiong; Baichuan Wang; Yingze Zhang
• Keywords: 0303 health sciences; 03 medical and health sciences; QH301-705.5; Physiology; QP1-981; Biology (General); Article; 3. Good health

The immune microenvironment extensively participates in tumorigenesis as well progression osteosarcoma (OS). However, the landscape and dynamics of cells OS are poorly characterized. By analyzing single-cell RNA sequencing (scRNA-seq) data, which characterize transcription state at resolution, we produced an atlas OS. results suggested that a cluster regulatory dendritic (DCs) might shape immunosuppressive by recruiting T cells. We also found major histocompatibility complex class I (MHC-I) molecules were downregulated cancer findings indicated reduction tumor immunogenicity OS, can be potential mechanism escape. Of note, CD24 was identified novel "don't eat me" signal contributed to evasion Altogether, our provide insights into suggesting myeloid-targeted immunotherapy could promising approach treat