The combination of complex karyotype subtypes and IGHV mutational status identifies new prognostic and predictive groups in chronic lymphocytic leukaemia

• DOI: 10.1038/s41416-019-0502-x
• Publication Date: 2019-06-17T23:04:55Z
• Authors: Andrea Visentin; Laura Bonaldi; Gian Matteo Rigolin; Francesca Romana ...; Annalisa Martines; Federica Frezzato; Silvia Imbergamo; Edoardo Scomazzon; Stefano Pravato; Maria Antonella B...; Maurizio Cavallari; Eleonora Volta; Francesco Cavazzini; Maurizio Nanni; Ilaria Del Giudice; Monica Facco; Anna Guarini; Gianpietro Semenzato; Robin Foà; Antonio Cuneo; Livio Trentin
• Keywords: IGHV@; Chemoimmunotherapy

Complex karyotype (CK) is a heterogeneous category with negative impact in chronic lymphocytic leukaemia (CLL). Our group has recently reported that CK patients major structural abnormalities (i.e. CK2) are characterised by worse prognosis, as compared to other lesions within CK(CK1).We performed multicentre retrospective study test whether the combination of subtypes IGHV status could be relevant prognostic and predictive tool.Among 522 13% harboured CK2, 41% CK1 and/or U-IGHV (U-CK1) 46% M-IGHV without any (M-noCK). After median follow-up 5.8 years, CK2 had shortest TTFT (5-year 31%, 39 81%, p < 0.0001) OS 67%, 85 93%, U-CK1 or M-noCK cases, regardless TP53 abnormalities. also worst outcome after chemoimmunotherapy. In fact, TTNT FCR BR was 1.86 4.79 years for U-CK1, but not reached (p 0.0005).We herein suggest combined assessment mutational refines prognostication CLL, allowing identify who an indolent disease excellent