HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect

• DOI: 10.1038/s41419-018-0626-6
• Publication Date: 2018-05-29T10:07:37Z
• Authors: Sijia He; Jin Cheng; Lianhui Sun; Yiwei Wang; Chuangui Wang; Xinjian Liu; Zhengxiang Zhang; Minghui Zhao; Yuntao Luo; Ling Tian; Chuanyuan Li; Qian Huang
• Keywords: HMGB1; RAGE

Abstract Tumor repopulation during therapy is an important cause of treatment failure. Strategies to overcome are arising in parallel with advances the comprehension underlying biological mechanisms. Here, we reveal a new mechanism by which high mobility group box 1 (HMGB1) released dying cells radiotherapy or chemotherapy could stimulate living tumor cell proliferationInhibition genetic ablation HMGB1 suppressed proliferation. This effect was due binding HMGB1with member receptor for advanced glycation end-products (RAGE), activated downstream ERK and p38 signaling pathway promoted Furthermore, higher expression tissue correlated poor overall survival concentration detected serum patients who accepted radiotherapy. Collectively, results from this study suggested that interaction between dead surviving might influence fate tumor. be novel promoter therapeutic prognostic relevance cancers.